Microcrystalline Cellulose Storage — MCC Pharmaceutical Excipient Tank Selection

Storing Microcrystalline Cellulose? Start Here

Microcrystalline cellulose (MCC) is a versatile powder used as a filler and binder in tablet manufacturing. It's a key ingredient in many pharmaceuticals due to its ability to compact easily, carry active ingredients, and aid tablet disintegration. MCC is a white, free-flowing powder derived from wood pulp and is safe for use in food and drugs. When storing MCC, focus on dust control, moisture management, and preventing metal contamination.

Can you store it in a poly tank?

Polyethylene tanks are not recommended for primary storage of MCC in pharmaceutical applications. MCC is best stored in 316L stainless steel tanks to prevent contamination and ensure compliance with cGMP standards. Poly tanks may be used for lab-scale storage if they meet FDA and USP standards.

Key Issue: Dust and Contamination Control

When handling MCC, controlling dust and avoiding contamination are crucial. MCC is prone to electrostatic accumulation, which can lead to dust explosions if not managed properly. Use stainless steel equipment to minimize the risk of metal particulate contamination and ensure a clean, safe storage environment.

The safety that actually matters

• Use 316L stainless steel for primary contact surfaces to prevent contamination.
• Ensure proper dust control measures to avoid electrostatic hazards.
• Maintain a dry storage environment to prevent moisture uptake.

Common questions

Is microcrystalline cellulose safe for food and pharma use?

Yes, MCC is generally recognized as safe (GRAS) for food and is widely used in pharmaceuticals.

What materials are suitable for storing MCC?

316L stainless steel is preferred for primary storage. Poly tanks can be used at lab scale if compliant with FDA and USP standards.

How do you prevent MCC from clumping?

Store MCC in a dry environment and use equipment designed to promote mass flow, such as sloped bins and vibrating activators.